Integrative development of smart drug-vector nanostructures for

Paul Clayton-arkiv – Food Pharmacy

The basic mechanisms of stimuli‐responsive drug delivery systems can be described as follows: after injection, the stimuli‐responsive drug delivery system (nanocarriers) accumulates at a tumor site via passive (enhanced permeability and retention effect) or active (receptor–ligand affinity) targeting. Stimuli‐responsive nanotherapeutics for precision drug delivery and cancer therapy Yiting Qiao The First Affiliated Hospital; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases; Key Laboratory of Combined Multi‐Organ Transplantation, Ministry of Public Health, School of Medicine, Zhejiang University, Hangzhou, P.R. China The discussion goes from stimuli‐responsive polymers with responsive backbones or modified by responsive functional groups for drug encapsulation and release to polymer–drug conjugates with responsive covalent linkages. Stimuli-responsive drug delivery systems (DDS) appear as a promising approach to control and target drug delivery. When these DDS are administered, the drug release is activated and then modulated through some action or external input and facilitated by the energy supplied externally. The stimuli-responsive nanocarriers for drug delivery to tumors towards precision imaging, effective therapy and theranostics.

Stimuli responsive drug delivery

A greater amount of MRSA in the system will lead to more release of drug and vice versa. Adv Drug Deliv Rev. 2013 Nov;65(13-14):1699-715. doi: 10.1016/j.addr.2013.04.011. Epub 2013 Apr 20. Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor. 2.

Strategies adopted in the design of stimuli-responsive 2013-02-01 · Schematic exemplification of the drug release mechanism from a hydrogel stimuli-responsive electric delivery system. Adapted from Liu et al.

Modulation of the tumor microenvironment by intratumoral

Enhancing drug delivery by micro- and nanoparticle is a successful of magnetic field-responsive hemicellulose hydrogels for drug delivery In Situ Cross-Linking of Stimuli-Responsive Hemicellulose Microgels during Spray av L Nyström · 2018 — Microgels are weakly cross-linked polymer colloids, which can be made responsive to various stimuli. In the context of drug delivery, microgels Stretchable Sensors with Tunability and Single Stimuli-Responsive ness through Reactive oxygen species responsive nanoplatforms as smart drug delivery Stimuli-responsive hydrogels (a group of polymers) have attracted a lot of Although it was previously used in drug- and DNA- delivery systems, it has not (to May 2005; Nature Reviews Drug Discovery 4(4):298-306 Schematic illustration of protein release from a polymer sensitive to external such as targeted delivery and responsiveness to external stimuli.

Publications – Laboratory of Molecular Materials at Linköping

Garlic Title: Stimuli-Responsive Molecularly Imprinted Polymers for Drug Delivery: A Review VOLUME: 5 ISSUE: 2 Author(s):Francesco Puoci, Francesca Iemma and Nevio Picci Affiliation:Dipartimento di Scienze Farmaceutiche, Universita della Calabria - Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy. Keywords:Molecularly imprinted polymers, stimuli-responsive systems, intelligent drug delivery Traditional drug-delivery systems suffer some drawbacks, especially premature drug release and the lack of diverse stimuli responsiveness. The partnership between suitable solid support-based drug nanocarriers and supramolecular nanovalves led to a variety of gated materials containing supramolecular switches and polymers that are capable of targeted delivery and on-demand release … 2019-07-12 Stimuli-responsive Pd 2 L 4 metallosupramolecular cages: towards targeted cisplatin drug delivery† James E. M. Lewis , a Emma L. Gavey , a Scott A. Cameron a and James D. Crowley * a Among various types of stimuli‐responsive drug delivery systems, reduction‐responsive polymers have attracted great interest.

In this study, we reviewed state-of-the-art endogenous-based and exogenous-based stimuli-responsive drug delivery systems (DDS) for programmed site-specific release to overcome the drawbacks of conventional therapeutic modalities. Stimuli-responsive materials, which exhibit changes in one or more properties in response to an external trigger, have gained interest due to their tunability and versatility. Our group has prepared stimuli-responsive materials including hydrogels, peptides, and nanoparticles for drug delivery applications. These materials are responsive to a variety of triggers such as pH, reducing conditions, temperature, glucose, and enzymes that can be tuned based on their chemistry for various The basic mechanisms of stimuli‐responsive drug delivery systems can be described as follows: after injection, the stimuli‐responsive drug delivery system (nanocarriers) accumulates at a tumor site via passive (enhanced permeability and retention effect) or active (receptor–ligand affinity) targeting. Stimuli-responsive particles could find use in numerous applications in the chemical, coatings, cosmetic, detergent and food industries, as well as drug delivery and diagnostics where the stimuli Thermoresponsive and other stimuli-responsive polymers employed in drug delivery systems can be activated via ultrasound stimulation. Polyethylene oxide/polypropylene oxide co-block or triblock polymers and polymethacrylates are thermal- and pH-responsive polymer groups, resp.
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Aili "Coiled Coil-Based Therapeutics and Drug Delivery Systems", Adv. Drug “Peptide Functionalized Gold Nanoparticles as a Stimuli Responsive Contrast Multifunctional mesoporous silica nanospheres for biosensor, stimuli-responsive controlled-release drug delivery carriers and gene transfection vectors;The W. Zhao et al., "In Situ Cross-Linking of Stimuli-Responsive Hemicellulose Field-Responsive Hemicellulose Hydrogels for Drug Delivery," tumour tissue where a stimuli-responsive mechanism releases the anti-tumor drug(s). Enhancing drug delivery by micro- and nanoparticle is a successful of magnetic field-responsive hemicellulose hydrogels for drug delivery In Situ Cross-Linking of Stimuli-Responsive Hemicellulose Microgels during Spray av L Nyström · 2018 — Microgels are weakly cross-linked polymer colloids, which can be made responsive to various stimuli.

No. 577030), ferrocene, and carbon nanotubes. The increased understanding of molecular aspects associated with chronic diseases, such as cancer and the role of tumor microenvironment, has led to the identification of endogenous and exogenous stimuli that can be exploited to devise “stimuli-responsive” materials for site-specific drug delivery applications. Stimuli-responsive drug-delivery nanocarriers (DDNs) have been increasingly reported in the literature as an alternative for breast cancer therapy. Stimuli-responsive materials, which exhibit changes in one or more properties in response to an external trigger, have gained interest due to their tunability and versatility.
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In this study, we reviewed state-of-the-art endogenous-based and exogenous-based stimuli-responsive drug delivery systems (DDS) for programmed site-specific release to overcome the drawbacks of conventional therapeutic modalities. This particular work focuses on the smart chemistry and mechanism of action aspects of several types of stimuli-responsive … Stimuli-responsive hydrogels in drug delivery and tissue engineering Nikhil Sood, Ankur Bhardwaj, Shuchi Mehta, and Abhinav Mehta Nanomedicine Research Centre, ISF College of Pharmacy Ferozepur, Moga, Punjab, India Abstract Hydrogels are the three-dimensional network structures obtained from a … Magnetic‐responsive drug delivery is a unique technique using the influence of an external magnetic field, which cannot only precisely drive the drug‐loaded magnetic NPs to the intended site to improve therapeutic efficacy, but also serve as an external stimulus to trigger a controllable release of the drug… Stimuli-Responsive Nano-Architecture Drug-Delivery Systems to Solid Tumor Micromilieu: Past, Present, and Future Perspectives Hossam S. El-Sawy Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo 63514, Egypt Dendrimers have shown great promise as carriers in drug delivery due to their unique structures and superior properties. However, the precise control of payload release from a dendrimer matrix still presents a great challenge. Stimuli-responsive dendrimers that release payloads in response … Strategies To Design and Synthesize Polymer‐Based Stimuli‐Responsive Drug‐Delivery Nanosystems Xing Qin Laboratory of Low-Dimensional Materials Chemistry, Key … Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics Peng Mi Department of Radiology, Center for Medical Imaging, and State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, No.17 South Renmin Road, Chengdu, 610041, China Spurred by recent progress in materials chemistry and drug delivery, stimuli-responsive devices that deliver a drug in spatial-, temporal- and dosage-controlled fashions have become possible.

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Köp Stimuli-responsive Drug Delivery Systems av Amit Singh, Mansoor M Amiji på Bokus.com. pH-responsive systems take advantage of the significant variations in pH to stimulate localized drug delivery to different regions of the body such as the gastrointestinal tract, tumor microenvironment, or to the endosomal/lysosomal compartments of the cell (Figure 1). Stimuli-responsive drug-delivery nanocarriers (DDNs) have been increasingly reported in the literature as an alternative for breast cancer therapy. Stimuli-responsive DDNs are developed with materials that present a drastic change in response to intrinsic/chemical stimuli (pH, redox and enzyme) and extrinsic/physical stimuli (ultrasound, Near-infrared (NIR) light, magnetic field and electric current). Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications, Volume One: Types and Triggers discusses, in detail, the recent trends in designing biodegradable and biocompatible single-responsive polymers and nanoparticles for safe drug delivery. Focusing on the most advanced materials and technologies, evaluation methods, and advanced synthesis techniques stimuli-responsive 2021-01-01 · Designing different stimuli-responsive drug delivery based on CD. At the end of the 20th century, heat-sensitive liposomes were used for local drug release to treat diseases, triggering the concept of stimuli-responsive drug delivery system ( Yatvin, Weinstein, Dennis, & Blumenthal, 1978 ). The basic mechanisms of stimuli‐responsive drug delivery systems can be described as follows: after injection, the stimuli‐responsive drug delivery system (nanocarriers) accumulates at a tumor site via passive (enhanced permeability and retention effect) or active (receptor–ligand affinity) targeting.